Translating research

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Our Goal

$ 186,000

Your funding will see laboratory research enter clinical trials to treat bone & soft tissue cancer in children

Clinical translation of CAR T cell therapy for the treatment of sarcoma

Sarcoma is an aggressive cancer that comprises 20% of all childhood cancers with 20-25% of children not surviving beyond five years.

Commonly occurring in children and young adults, sarcomas express tumour specific proteins or antigens (a protein or other molecule found only on cancer cells and not on normal cells). Current treatments for sarcoma are inadequate with novel treatments required to improve outcomes.

Immunotherapy with genetically modified immune T cells expressing chimeric antigen receptors (CAR T cells: a special receptor created in the laboratory designed to bind to certain proteins on cancer cells) has revolutionised cancer treatment, especially for haematological malignancies. The aim of this project is to focus on the clinical translation of the laboratory tested CAR T cells into Phase 1 trials for paediatric sarcoma patients and to extend this exciting and powerful technology on solid tumours, like sarcoma.

Recipient

A/Professor Geoff McCowage & Dr Kavitha Gowrishankar

Institute

Children's Hospital Westmead

The Kids' Cancer Project Funding

$186,000 (July 2022 - June 2024)

Other Funding

Tye Dye Foundation Funding: $45,000
Children's Cancer Research Unit Funding: $50,000

Total Funding

$281,000

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Sarcoma (bone & soft tissue cancer)

Clinical translation of laboratory tested CAR T cell therapy into Phase 1 trials for paediatric treatment of sarcoma.

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